منابع مشابه
Human whole-genome shotgun sequencing.
Large-scale sequencing of the human genome is now under way (Boguski et al. 1996; Marshall and Pennisi 1996). Although at the beginning of the Genome Project, many doubted the scientific value of sequencing the entire human genome, these doubts have evaporated almost entirely (Gibbs 1995; Olson 1995). Primary reasons for generating the human genomic sequence are listed in Table 1. The approach ...
متن کاملAn Algorithm for Whole Genome Shotgun Sequencing
The push to sequence the entire human genome is gearing up [1]. Recently there has been disagreement within the genome community as to the best approach for sequencing the human genome. While many scientists believe that clone mapping is the best solution, others argue that whole genome shotgun sequencing is a cheaper and faster alternative. Arguments for [2] and against [3] whole genome shotgu...
متن کاملA Dataset Generator for Whole Genome Shotgun Sequencing
Simulated data sets have been found to be useful in developing software systems because (1) they allow one to study the effect of a particular phenomenon in isolation, and (2) one has complete information about the true solution against which to measure the results of the software. In developing a software suite for assembling a whole human genome shotgun data set, we have developed a simulator...
متن کاملWhole-genome shotgun sequencing of mitochondria from ancient hair shafts.
Although the application of sequencing-by-synthesis techniques to DNA extracted from bones has revolutionized the study of ancient DNA, it has been plagued by large fractions of contaminating environmental DNA. The genetic analyses of hair shafts could be a solution: We present 10 previously unexamined Siberian mammoth (Mammuthus primigenius) mitochondrial genomes, sequenced with up to 48-fold ...
متن کاملBioinformatics for Whole-Genome Shotgun Sequencing of Microbial Communities
The application of whole-genome shotgun sequencing to microbial communities represents a major development in metagenomics, the study of uncultured microbes via the tools of modern genomic analysis. In the past year, whole-genome shotgun sequencing projects of prokaryotic communities from an acid mine biofilm, the Sargasso Sea, Minnesota farm soil, three deep-sea whale falls, and deep-sea sedim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Research
سال: 1997
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.7.5.401